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Involvement of MarR and YedS in carbapenem resistance in a clinical isolate of Escherichia coli from China.

ABSTRACT: A carbapenem-resistant clinical isolate of Escherichia coli, which lacked OmpF and OmpC porins, carried a marR mutation and expressed a functional yedS, a normally nontranslated gene. MarR and YedS are described here as having effects on the ability of this strain to resist carbapenems. Additionally, expression of YedS was regulated by the small RNA MicF in a MarA-dependent way. These findings illustrate how broadly bacteria can mutate within a selective clinical setting, in this case, resistance to carbapenems, by altering three porin genes and one regulatory gene.

SUBMITTER: Warner DM

PROVIDER: S-EPMC3623324 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Involvement of MarR and YedS in carbapenem resistance in a clinical isolate of Escherichia coli from China.

Warner Douglas M DM Yang Qiwen Q Duval Valérie V Chen Minjun M Xu Yingchun Y Levy Stuart B SB

Antimicrobial agents and chemotherapy 20130114 4

A carbapenem-resistant clinical isolate of Escherichia coli, which lacked OmpF and OmpC porins, carried a marR mutation and expressed a functional yedS, a normally nontranslated gene. MarR and YedS are described here as having effects on the ability of this strain to resist carbapenems. Additionally, expression of YedS was regulated by the small RNA MicF in a MarA-dependent way. These findings illustrate how broadly bacteria can mutate within a selective clinical setting, in this case, resistanc ...[more]

PMID: 23318808

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Dataset Information

Involvement of MarR and YedS in carbapenem resistance in a clinical isolate of Escherichia coli from China.

Publications

Involvement of MarR and YedS in carbapenem resistance in a clinical isolate of Escherichia coli from China.

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