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Seventy-five genetic loci influencing the human red blood cell.

ABSTRACT: Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P?

SUBMITTER: van der Harst P 

PROVIDER: S-EPMC3623669 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Seventy-five genetic loci influencing the human red blood cell.

van der Harst Pim P   Zhang Weihua W   Mateo Leach Irene I   Rendon Augusto A   Verweij Niek N   Sehmi Joban J   Paul Dirk S DS   Elling Ulrich U   Allayee Hooman H   Li Xinzhong X   Radhakrishnan Aparna A   Tan Sian-Tsung ST   Voss Katrin K   Weichenberger Christian X CX   Albers Cornelis A CA   Al-Hussani Abtehale A   Asselbergs Folkert W FW   Ciullo Marina M   Danjou Fabrice F   Dina Christian C   Esko Tõnu T   Evans David M DM   Franke Lude L   Gögele Martin M   Hartiala Jaana J   Hersch Micha M   Holm Hilma H   Hottenga Jouke-Jan JJ   Kanoni Stavroula S   Kleber Marcus E ME   Lagou Vasiliki V   Langenberg Claudia C   Lopez Lorna M LM   Lyytikäinen Leo-Pekka LP   Melander Olle O   Murgia Federico F   Nolte Ilja M IM   O'Reilly Paul F PF   Padmanabhan Sandosh S   Parsa Afshin A   Pirastu Nicola N   Porcu Eleonora E   Portas Laura L   Prokopenko Inga I   Ried Janina S JS   Shin So-Youn SY   Tang Clara S CS   Teumer Alexander A   Traglia Michela M   Ulivi Sheila S   Westra Harm-Jan HJ   Yang Jian J   Zhao Jing Hua JH   Anni Franco F   Abdellaoui Abdel A   Attwood Antony A   Balkau Beverley B   Bandinelli Stefania S   Bastardot François F   Benyamin Beben B   Boehm Bernhard O BO   Cookson William O WO   Das Debashish D   de Bakker Paul I W PI   de Boer Rudolf A RA   de Geus Eco J C EJ   de Moor Marleen H MH   Dimitriou Maria M   Domingues Francisco S FS   Döring Angela A   Engström Gunnar G   Eyjolfsson Gudmundur Ingi GI   Ferrucci Luigi L   Fischer Krista K   Galanello Renzo R   Garner Stephen F SF   Genser Bernd B   Gibson Quince D QD   Girotto Giorgia G   Gudbjartsson Daniel Fannar DF   Harris Sarah E SE   Hartikainen Anna-Liisa AL   Hastie Claire E CE   Hedblad Bo B   Illig Thomas T   Jolley Jennifer J   Kähönen Mika M   Kema Ido P IP   Kemp John P JP   Liang Liming L   Lloyd-Jones Heather H   Loos Ruth J F RJ   Meacham Stuart S   Medland Sarah E SE   Meisinger Christa C   Memari Yasin Y   Mihailov Evelin E   Miller Kathy K   Moffatt Miriam F MF   Nauck Matthias M   Novatchkova Maria M   Nutile Teresa T   Olafsson Isleifur I   Onundarson Pall T PT   Parracciani Debora D   Penninx Brenda W BW   Perseu Lucia L   Piga Antonio A   Pistis Giorgio G   Pouta Anneli A   Puc Ursula U   Raitakari Olli O   Ring Susan M SM   Robino Antonietta A   Ruggiero Daniela D   Ruokonen Aimo A   Saint-Pierre Aude A   Sala Cinzia C   Salumets Andres A   Sambrook Jennifer J   Schepers Hein H   Schmidt Carsten Oliver CO   Silljé Herman H W HH   Sladek Rob R   Smit Johannes H JH   Starr John M JM   Stephens Jonathan J   Sulem Patrick P   Tanaka Toshiko T   Thorsteinsdottir Unnur U   Tragante Vinicius V   van Gilst Wiek H WH   van Pelt L Joost LJ   van Veldhuisen Dirk J DJ   Völker Uwe U   Whitfield John B JB   Willemsen Gonneke G   Winkelmann Bernhard R BR   Wirnsberger Gerald G   Algra Ale A   Cucca Francesco F   d'Adamo Adamo Pio AP   Danesh John J   Deary Ian J IJ   Dominiczak Anna F AF   Elliott Paul P   Fortina Paolo P   Froguel Philippe P   Gasparini Paolo P   Greinacher Andreas A   Hazen Stanley L SL   Jarvelin Marjo-Riitta MR   Khaw Kay Tee KT   Lehtimäki Terho T   Maerz Winfried W   Martin Nicholas G NG   Metspalu Andres A   Mitchell Braxton D BD   Montgomery Grant W GW   Moore Carmel C   Navis Gerjan G   Pirastu Mario M   Pramstaller Peter P PP   Ramirez-Solis Ramiro R   Schadt Eric E   Scott James J   Shuldiner Alan R AR   Smith George Davey GD   Smith J Gustav JG   Snieder Harold H   Sorice Rossella R   Spector Tim D TD   Stefansson Kari K   Stumvoll Michael M   Tang W H Wilson WH   Toniolo Daniela D   Tönjes Anke A   Visscher Peter M PM   Vollenweider Peter P   Wareham Nicholas J NJ   Wolffenbuttel Bruce H R BH   Boomsma Dorret I DI   Beckmann Jacques S JS   Dedoussis George V GV   Deloukas Panos P   Ferreira Manuel A MA   Sanna Serena S   Uda Manuela M   Hicks Andrew A AA   Penninger Josef Martin JM   Gieger Christian C   Kooner Jaspal S JS   Ouwehand Willem H WH   Soranzo Nicole N   Chambers John C JC  

Nature 20121205 7429

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10(-8), which together explain 4-9% of the phenotypi  ...[more]

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