Ontology highlight
ABSTRACT:
SUBMITTER: Gbadegesin R
PROVIDER: S-EPMC3624015 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Pediatric nephrology (Berlin, Germany) 20101126 7
Focal and segmental glomerulosclerosis (FSGS) is an important cause of steroid-resistant nephrotic syndrome in adults and children. It is responsible for 5-20% of all cases of end-stage kidney disease (ESKD) in the United States. The pathogenesis of FSGS has not been fully elucidated; however, data from molecular studies of familial cases in the last two decades suggest that FSGS is a defect of the podocyte. The therapeutic agents available for treatment of FSGS are not very effective and only a ...[more]