Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC3624020 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Xu Jinbin J Zeng Chenbo C Chu Wenhua W Pan Fenghui F Rothfuss Justin M JM Zhang Fanjie F Tu Zhude Z Zhou Dong D Zeng Dexing D Vangveravong Suwanna S Johnston Fabian F Spitzer Dirk D Chang Katherine C KC Hotchkiss Richard S RS Hawkins William G WG Wheeler Kenneth T KT Mach Robert H RH
Nature communications 20110705
The sigma-2 receptor, whose gene remains to be cloned, has been validated as a biomarker for tumour cell proliferation. Here we report the use of a novel photoaffinity probe, WC-21, to identify the sigma-2 receptor-binding site. WC-21, a sigma-2 ligand containing both a photoactive azide moiety and a fluorescein isothiocyanate group, irreversibly labels sigma-2 receptors in rat liver; the membrane-bound protein was identified as PGRMC1 (progesterone receptor membrane component 1). Immunocytochem ...[more]