Ontology highlight
ABSTRACT:
SUBMITTER: McGuire MR
PROVIDER: S-EPMC9839567 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
McGuire Meredith R MR Espenshade Peter J PJ
Pharmacology & therapeutics 20221201
Progesterone Receptor Membrane Component 1 (PGRMC1) is a heme-binding protein that has been implicated in a wide range of cell and tissue functions, including cytochromes P450 activity, heme homeostasis, cancer, female reproduction, and protein quality control. Despite an extensive body of literature, a relative lack of mechanistic insight means that how PGRMC1 functions in these different aspects of biology is largely unknown. This review provides an overview of the PGRMC1 literature, highlight ...[more]