Ontology highlight
ABSTRACT:
SUBMITTER: Gorgun GT
PROVIDER: S-EPMC3624943 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Görgün Güllü Topal GT Whitehill Gregory G Anderson Jennifer L JL Hideshima Teru T Maguire Craig C Laubach Jacob J Raje Noopur N Munshi Nikhil C NC Richardson Paul G PG Anderson Kenneth C KC
Blood 20130115 15
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress immune responses. MDSCs have been characterized in infections, inflammatory diseases, and solid tumors; however, their presence and role in the tumor-promoting, immune-suppressive microenvironment in hematologic malignancies remains unclear. We assessed the presence, frequency, and functional characteristics of MDSCs in patients with newly diagnosed, relapsed, and relapsed/ ...[more]