Ontology highlight
ABSTRACT:
SUBMITTER: Binsfeld M
PROVIDER: S-EPMC5122361 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Binsfeld Marilène M Muller Joséphine J Lamour Virginie V De Veirman Kim K De Raeve Hendrik H Bellahcène Akeila A Van Valckenborgh Els E Baron Frédéric F Beguin Yves Y Caers Jo J Heusschen Roy R
Oncotarget 20160601 25
Multiple myeloma (MM) is a plasma cell malignancy characterized by the accumulation of tumor cells in the bone marrow (BM) and is associated with immunosuppression, angiogenesis and osteolysis. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature, immunosuppressive myeloid cells that promote tumor progression through different mechanisms.In this work, we studied the contribution of MDSC subsets to different disease-promoting aspects in MM. We observed an expa ...[more]