Ontology highlight
ABSTRACT:
SUBMITTER: Williams RT
PROVIDER: S-EPMC3625460 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Williams Renee T RT Nalbandian Jenifer N JN Tu Audrey A Wang Yinsheng Y
Clinica chimica acta; international journal of clinical chemistry 20121222
<h4>Background</h4>The primary mode of action for cis-diamminedichloroplatinum (II), referred to as cisplatin, toward the treatment of solid malignancies is through formation of cross-links with DNA at purine sites, especially guanines.<h4>Methods</h4>We prepared oligodeoxyribonucleotides (ODNs) containing a 1,2-GpG, 1,2-ApG, or 1,3-GpXpG cisplatin intrastrand cross-link and the corresponding ODNs modified with (15)N2-labeled cisplatin, and characterized these ODNs with electrospray ionization m ...[more]