Ontology highlight
ABSTRACT:
SUBMITTER: Jin B
PROVIDER: S-EPMC3625945 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Cell reports 20121121 5
DNA methylation, mediated by the combined action of three DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B), is essential for mammalian development and is a major contributor to cellular transformation. To elucidate how DNA methylation is targeted, we mapped the genome-wide localization of all DNMTs and methylation, and examined the relationships among these markers, histone modifications, and nucleosome structure in a pluripotent human tumor cell line in its undifferentiated and differentiated ...[more]