Ontology highlight
ABSTRACT:
SUBMITTER: Costas C
PROVIDER: S-EPMC3079358 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Costas Celina C de la Paz Sanchez Maria M Stroud Hume H Yu Yanchun Y Oliveros Juan Carlos JC Feng Suhua S Benguria Alberto A López-Vidriero Irene I Zhang Xiaoyu X Solano Roberto R Jacobsen Steven E SE Gutierrez Crisanto C
Nature structural & molecular biology 20110206 3
Genome integrity requires faithful chromosome duplication. Origins of replication, the genomic sites at which DNA replication initiates, are scattered throughout the genome. Their mapping at a genomic scale in multicellular organisms has been challenging. In this study we profiled origins in Arabidopsis thaliana by high-throughput sequencing of newly synthesized DNA and identified ~1,500 putative origins genome-wide. This was supported by chromatin immunoprecipitation and microarray (ChIP-chip) ...[more]