Ontology highlight
ABSTRACT:
SUBMITTER: Xu PT
PROVIDER: S-EPMC3625967 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Xu Pu-Ting PT Li Yi-Ju YJ Qin Xue-Jun XJ Kroner Charles C Green-Odlum Anya A Xu Hong H Wang Tian-Yuan TY Schmechel Donald E DE Hulette Christine M CM Ervin John J Hauser Mike M Haines Jonathan J Pericak-Vance Margaret A MA Gilbert John R JR
Molecular and cellular neurosciences 20070724 3
APOE4 allele is a major risk factor for late-onset Alzheimer disease (AD). The mechanism of action of APOE in AD remains unclear. To study the effects of APOE alleles on gene expression in AD, we have analyzed the gene transcription patterns of human hippocampus from APOE3/3, APOE3/4, APOE4/4 AD patients and normal control using Serial Analysis of Gene Expression (SAGE). Using SAGE, we found gene expression patterns in hippocampus of APOE3/4 and APOE4/4 AD patients differ substantially from thos ...[more]