Ontology highlight
ABSTRACT:
SUBMITTER: Kawashima SA
PROVIDER: S-EPMC3626098 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Chemistry & biology 20130201 2
Protein kinases may function more like variable rheostats rather than two-state switches. However, we lack approaches to properly analyze this aspect of kinase-dependent regulation. To address this, we develop a strategy in which a kinase inhibitor is identified using genetics-based screens, kinase mutations that confer resistance are characterized, and dose-dependent responses of isogenic drug-sensitive and resistant cells to inhibitor treatments are compared. This approach has the advantage th ...[more]