Ontology highlight
ABSTRACT:
SUBMITTER: Yeung F
PROVIDER: S-EPMC4182313 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Oncogene 20140331 6
Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability and metabolism. Although these NAD(+)-dependent deacetylases control adaptive cellular responses, identification of sirtuin-regulated signaling targets remain under-studied. Here, we demonstrate that acetylation of the mitogen-activated protein kinase kinase-1 (MEK1) stimulates its kinase activity, and that acetylated MEK1 is under the regulatory control of the sirtuin family m ...[more]