Ontology highlight
ABSTRACT:
SUBMITTER: Qiu QW
PROVIDER: S-EPMC3626844 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Qiu Qin-Wei QW Wu Dong-Dong DD Yu Li-Hua LH Yan Ti-Zhen TZ Zhang Wen W Li Zhe-Tao ZT Liu Yan-Hui YH Zhang Ya-Ping YP Xu Xiang-Min XM
BMC evolutionary biology 20130311
<h4>Background</h4>The Southeast Asian deletion (--(SEA)) is the most commonly observed mutation among diverse α-thalassemia alleles in Southeast Asia and South China. It is generally argued that mutation --(SEA), like other variants causing hemoglobin disorders, is associated with protection against malaria that is endemic in these regions. However, little evidence has been provided to support this claim.<h4>Results</h4>We first examined the genetic imprint of recent positive selection on the - ...[more]