Ontology highlight
ABSTRACT:
SUBMITTER: Su X
PROVIDER: S-EPMC3626990 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 20130401 2
microRNAs (miRNAs) are a class of endogenous, single-stranded non-coding RNAs of 20-23 nucleotides in length, functioning as negative regulators of gene expression at the post-transcriptional level. The dysregulation of miRNAs has been demonstrated to play critical roles in tumorigenesis, either through inhibiting tumor suppressor genes or activating oncogenes inappropriately. Besides their promising clinical applications in cancer diagnosis and treatment, recent studies have uncovered that miRN ...[more]