Ontology highlight
ABSTRACT:
SUBMITTER: Komarova YA
PROVIDER: S-EPMC3627495 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Komarova Yulia A YA Huang Fei F Geyer Melissa M Daneshjou Nazila N Garcia Alexander A Idalino Luiza L Kreutz Barry B Mehta Dolly D Malik Asrar B AB
Molecular cell 20121115 6
Vascular endothelial (VE)-cadherin homophilic adhesion controls endothelial barrier permeability through assembly of adherens junctions (AJs). We observed that loss of VE-cadherin-mediated adhesion induced the activation of Src and phospholipase C (PLC)γ2, which mediated Ca(2+) release from endoplasmic reticulum (ER) stores, resulting in activation of calcineurin (CaN), a Ca(2+)-dependent phosphatase. Downregulation of CaN activity induced phosphorylation of serine 162 in end binding (EB) protei ...[more]