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N-(2,6-Dimeth-oxy-pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide.

ABSTRACT: In the title compound, C20H19N3O4S, a novel tubulin ligand active against human cancer, the dihedral angle between the pyridine ring and the carbazole ring system is 42.87?(10)°. In the crystal, the mol-ecules are held together by N-H?O and C-H?O hydrogen bonds into layers, which are assembled into a three-dimensional network via ?-? stacking inter-actions between inversion-related pyridine rings, with centroid-centroid distances of 3.5101?(12)?Å.

SUBMITTER: Shan G

PROVIDER: S-EPMC3629629 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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N-(2,6-Dimeth-oxy-pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide.

Shan Guangzhi G Li Zhuorong Z Hu Laixing L Jiang Jiandong J Liu Zongying Z

Acta crystallographica. Section E, Structure reports online 20130323 Pt 4

In the title compound, C20H19N3O4S, a novel tubulin ligand active against human cancer, the dihedral angle between the pyridine ring and the carbazole ring system is 42.87 (10)°. In the crystal, the mol-ecules are held together by N-H⋯O and C-H⋯O hydrogen bonds into layers, which are assembled into a three-dimensional network via π-π stacking inter-actions between inversion-related pyridine rings, with centroid-centroid distances of 3.5101 (12) Å. ...[more]

PMID: 23634116

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