Ontology highlight
ABSTRACT:
SUBMITTER: Pal P
PROVIDER: S-EPMC3630103 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Pal Pankaj P Dowd Kimberly A KA Brien James D JD Edeling Melissa A MA Gorlatov Sergey S Johnson Syd S Lee Iris I Akahata Wataru W Nabel Gary J GJ Richter Mareike K S MK Smit Jolanda M JM Fremont Daved H DH Pierson Theodore C TC Heise Mark T MT Diamond Michael S MS
PLoS pathogens 20130418 4
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the development of therapeutic agents, we screened 230 new mouse anti-CHIKV monoclonal antibodies (MAbs) for their ability to inhibit infection of all three CHIKV genotypes. Four of 36 neutralizing MAbs (CHK-102, CHK-152, CHK-166, and CHK-263) provided complete protection against lethality as prophylaxis in highly susceptible immun ...[more]