Ontology highlight
ABSTRACT:
SUBMITTER: Villa M
PROVIDER: S-EPMC4999520 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Nature communications 20160824
Epithelia function as barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). However, AhR function in these tissues is unknown. Here we show that AhR regulates multiciliogenesis in both murine airway epithelia and in Xenopus laevis epidermis. In air-exposed airway epithelia, induction of factors required for multiciliogenesis, including cyclin O (Ccno) and Multicilin (Mcidas), is AhR dependent, and air exposure induces AhR binding to the Ccno ...[more]