Ontology highlight
ABSTRACT:
SUBMITTER: Mahajan N
PROVIDER: S-EPMC3630891 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20130307 16
Maspin is a member of the serine protease inhibitor (serpin) superfamily and displays tumor-suppressing activity by controlling cell migration, proliferation, apoptosis, and adhesion. Here, we provide evidence that maspin acts as a reactive oxygen species (ROS) scavenger through oxidation of three structurally exposed cysteine thiols to sulfenic acid. Ablation of these cysteine residues in maspin resulted in a significant increase in total ROS production in mouse mammary TM40D cells. Also, cells ...[more]