Analysis and functional prediction of reactive cysteine residues.
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ABSTRACT:
SUBMITTER: Marino SM
PROVIDER: S-EPMC3281665 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Analysis and functional prediction of reactive cysteine residues.
Marino Stefano M SM Gladyshev Vadim N VN
The Journal of biological chemistry 20111206 7
Cys is much different from other common amino acids in proteins. Being one of the least abundant residues, Cys is often observed in functional sites in proteins. This residue is reactive, polarizable, and redox-active; has high affinity for metals; and is particularly responsive to the local environment. A better understanding of the basic properties of Cys is essential for interpretation of high-throughput data sets and for prediction and classification of functional Cys residues. We provide an ...[more]
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