Ontology highlight
ABSTRACT:
SUBMITTER: Cordina NM
PROVIDER: S-EPMC3631366 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Cordina Nicole M NM Liew Chu Kong CK Gell David A DA Fajer Piotr G PG Mackay Joel P JP Brown Louise J LJ
Protein science : a publication of the Protein Society 20120901 9
Cardiac troponin C (cTnC) is the calcium binding subunit of the troponin complex that triggers the thin filament response to calcium influx into the sarcomere. cTnC consists of two globular EF-hand domains (termed the N- and C-domains) connected by a flexible linker. While the conformation of each domain of cTnC has been thoroughly characterized through NMR studies involving either the isolated N-domain (N-cTnC) or C-domain (C-cTnC), little attention has been paid to the range of interdomain ori ...[more]