Ontology highlight
ABSTRACT:
SUBMITTER: Lee MD
PROVIDER: S-EPMC5812434 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Lee M D MD Loh C-T CT Shin J J Chhabra S S Dennis M L ML Otting G G Swarbrick J D JD Graham B B
Chemical science 20150225 4
The design, synthesis and evaluation of four novel lanthanide-binding tags for paramagnetic NMR spectroscopy are reported. Each tag is based on the ((2<i>S</i>,2'<i>S</i>,2''<i>S</i>,2'''<i>S</i>)-1,1',1'',1'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis(propan-2-ol)) scaffold, featuring small chiral alcohol coordinating pendants to minimise the size and hydrophobic character of each tag. The tags feature different linkers of variable length for conjugation to protein <i>via</i> a ...[more]