Ontology highlight
ABSTRACT:
SUBMITTER: Brigham JL
PROVIDER: S-EPMC3631427 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
ACS chemical biology 20130123 4
Bioorthogonal ligation methods that allow the selective conjugation of fluorophores or biotin to proteins and small molecule probes that contain inert chemical handles are an important component of many chemical proteomic strategies. Here, we present a new catch-and-release enrichment strategy that utilizes a hexylchloride group as a bioorthogonal chemical handle. Proteins and small molecules that contain a hexylchloride tag can be efficiently captured by an immobilized version of the self-label ...[more]