Ontology highlight
ABSTRACT:
SUBMITTER: Lu L
PROVIDER: S-EPMC3631602 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20130213 6
The total syntheses of amphidinolide B1 and the proposed structure of amphidinolide B2 have been accomplished. Key aspects of this work include the development of a practical, non-transition-metal-mediated method for the construction of the C13-C15 diene, the identification of α-chelation and dipole minimization models for diastereoselective methyl ketone aldol reactions, the discovery of a spontaneous Horner-Wadsworth-Emmons macrocyclization strategy, and the development of a novel late stage m ...[more]