Ontology highlight
ABSTRACT:
SUBMITTER: Eggermann E
PROVIDER: S-EPMC3631701 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Eggermann Emmanuel E Jonas Peter P
Nature neuroscience 20111204 1
Parvalbumin is thought to act in a manner similar to EGTA, but how a slow Ca(2+) buffer affects nanodomain-coupling regimes at GABAergic synapses is unclear. Direct measurements of parvalbumin concentration and paired recordings in rodent hippocampus and cerebellum revealed that parvalbumin affects synaptic dynamics only when expressed at high levels. Modeling suggests that, in high concentrations, parvalbumin may exert BAPTA-like effects, modulating nanodomain coupling via competition with loca ...[more]