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Sequence-specific electron injection into DNA from an intermolecular electron donor.


ABSTRACT: Electron transfer in DNA has been intensively studied to elucidate its biological roles and for applications in bottom-up DNA nanotechnology. Recently, mechanisms of electron transfer to DNA have been investigated; however, most of the systems designed are intramolecular. Here, we synthesized pyrene-conjugated pyrrole-imidazole polyamides (PPIs) to achieve sequence-specific electron injection into DNA in an intermolecular fashion. Electron injection from PPIs into DNA was detected using 5-bromouracil as an electron acceptor. Twelve different 5-bromouracil-containing oligomers were synthesized to examine the electron-injection ability of PPI. Product analysis demonstrated that the electron transfer from PPIs was localized in a range of 8 bp from the binding site of the PPIs. These results demonstrate that PPIs can be a useful tool for sequence-specific electron injection.

SUBMITTER: Morinaga H 

PROVIDER: S-EPMC3632121 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Sequence-specific electron injection into DNA from an intermolecular electron donor.

Morinaga Hironobu H   Takenaka Tomohiro T   Hashiya Fumitaka F   Kizaki Seiichiro S   Hashiya Kaori K   Bando Toshikazu T   Sugiyama Hiroshi H  

Nucleic acids research 20130225 8


Electron transfer in DNA has been intensively studied to elucidate its biological roles and for applications in bottom-up DNA nanotechnology. Recently, mechanisms of electron transfer to DNA have been investigated; however, most of the systems designed are intramolecular. Here, we synthesized pyrene-conjugated pyrrole-imidazole polyamides (PPIs) to achieve sequence-specific electron injection into DNA in an intermolecular fashion. Electron injection from PPIs into DNA was detected using 5-bromou  ...[more]

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