Ontology highlight
ABSTRACT:
SUBMITTER: Tian G
PROVIDER: S-EPMC3632286 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Tian Geng G Singh Umashankar U Yu Yang Y Ellsworth Buffy S BS Hemberger Myriam M Geyer Rudolf R Stewart M David MD Behringer Richard R RR Fundele Reinald R
Developmental dynamics : an official publication of the American Association of Anatomists 20080501 5
The LIM homeobox containing genes of the LIM-3 group, Lhx3 and Lhx4, are critical for normal development. Both genes are involved in the formation of the pituitary and the motoneuron system and loss of either gene causes perinatal lethality. Previous studies had shown that Lhx3 is overexpressed in hyperplastic placentas of mouse interspecies hybrids. To determine the role of LHX3 in the mouse placenta, we performed expression and function analyses. Our results show that Lhx3 exhibits specific sp ...[more]