Ontology highlight
ABSTRACT:
SUBMITTER: Kurinna S
PROVIDER: S-EPMC3632650 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Kurinna Svitlana S Stratton Sabrina A SA Coban Zeynep Z Schumacher Jill M JM Grompe Markus M Duncan Andrew W AW Barton Michelle Craig MC
Hepatology (Baltimore, Md.) 20130215 5
<h4>Unlabelled</h4>Functions of p53 during mitosis reportedly include prevention of polyploidy and transmission of aberrant chromosomes. However, whether p53 plays these roles during genomic surveillance in vivo and, if so, whether this is done via direct or indirect means remain unknown. The ability of normal, mature hepatocytes to respond to stimuli, reenter the cell cycle, and regenerate liver mass offers an ideal setting to assess mitosis in vivo. In quiescent liver, normally high ploidy lev ...[more]