Ontology highlight
ABSTRACT:
SUBMITTER: Goodman AL
PROVIDER: S-EPMC3632886 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Goodman Anna L AL Forbes Emily K EK Williams Andrew R AR Douglas Alexander D AD de Cassan Simone C SC Bauza Karolis K Biswas Sumi S Dicks Matthew D J MD Llewellyn David D Moore Anne C AC Janse Chris J CJ Franke-Fayard Blandine M BM Gilbert Sarah C SC Hill Adrian V S AV Pleass Richard J RJ Draper Simon J SJ
Scientific reports 20130101
Rodent malaria species Plasmodium yoelii and P. chabaudi have been widely used to validate vaccine approaches targeting blood-stage merozoite antigens. However, increasing data suggest the P. berghei rodent malaria may be able to circumvent vaccine-induced anti-merozoite responses. Here we confirm a failure to protect against P. berghei, despite successful antibody induction against leading merozoite antigens using protein-in-adjuvant or viral vectored vaccine delivery. No subunit vaccine approa ...[more]