Ontology highlight
ABSTRACT:
SUBMITTER: Richie DL
PROVIDER: S-EPMC3632958 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Richie Daryl L DL Thompson Katherine V KV Studer Christian C Prindle Vivian C VC Aust Thomas T Riedl Ralph R Estoppey David D Tao Jianshi J Sexton Jessica A JA Zabawa Thomas T Drumm Joseph J Cotesta Simona S Eichenberger Jürg J Schuierer Sven S Hartmann Nicole N Movva N Rao NR Tallarico John A JA Ryder Neil S NS Hoepfner Dominic D
Antimicrobial agents and chemotherapy 20130311 5
High-throughput phenotypic screening against the yeast Saccharomyces cerevisiae revealed a series of triazolopyrimidine-sulfonamide compounds with broad-spectrum antifungal activity, no significant cytotoxicity, and low protein binding. To elucidate the target of this series, we have applied a chemogenomic profiling approach using the S. cerevisiae deletion collection. All compounds of the series yielded highly similar profiles that suggested acetolactate synthase (Ilv2p, which catalyzes the fir ...[more]