Dataset Information

Safety and immunogenicity of 2009 pH1N1 vaccination in HIV-infected pregnant women.

ABSTRACT:

Background

Pregnant women infected with human immunodeficiency virus (HIV) may have particular vulnerability to 2009 pandemic H1N1 influenza (pH1N1) infection. The safety and immunogenicity of pH1N1 vaccination in HIV-infected pregnant women are unknown.

Methods

HIV-infected women 18-39 years of age and 14-34 weeks' gestation on antiretroviral therapy received two 30-?g doses of unadjuvanted, inactivated pH1N1 vaccine 21 days apart. Hemagglutination inhibition titers were measured at entry, 21 days after dose 1, and 10 and 21 days after dose 2, and, in mothers and infants, at delivery and 3 and 6 months postdelivery.

Results

No severe vaccine-related adverse events were observed among 127 subjects. At entry, 21% had seroprotective (?1:40) titers. Seroprotection and seroresponse (?4-fold rise) occurred in 73% and 66% after dose 1 and 80% and 72% after dose 2, respectively. Of women lacking seroprotection at entry, 66% attained seroprotection after dose 1 and 75% after dose 2. Seroprotective titers were present in 67% of mothers and 65% of infants at delivery (median 66 days after dose 2), 60% of mothers and 26% of infants at 3 months postdelivery, and 59% of mothers and 12% of infants at 6 months postdelivery.

Conclusions

Two 30-?g doses were moderately immunogenic in HIV-infected pregnant women. No concerning vaccine-related safety signals were observed. Seroprotection persisted in most women postpartum. Efficient transplacental antibody transfer occurred, but seroprotection in infants waned rapidly. Vaccination to protect HIV-infected pregnant women and their newborns from new influenza strains is feasible, but more immunogenic platforms should be evaluated. Clinical Trials Registration. NCT00992017.

SUBMITTER: Abzug MJ

PROVIDER: S-EPMC3634309 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Publications

Safety and immunogenicity of 2009 pH1N1 vaccination in HIV-infected pregnant women.

Abzug Mark J MJ Nachman Sharon A SA Muresan Petronella P Handelsman Edward E Watts D Heather DH Fenton Terence T Heckman Barbara B Petzold Elizabeth E Weinberg Adriana A Levin Myron J MJ

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20130201 10

<h4>Background</h4>Pregnant women infected with human immunodeficiency virus (HIV) may have particular vulnerability to 2009 pandemic H1N1 influenza (pH1N1) infection. The safety and immunogenicity of pH1N1 vaccination in HIV-infected pregnant women are unknown.<h4>Methods</h4>HIV-infected women 18-39 years of age and 14-34 weeks' gestation on antiretroviral therapy received two 30-μg doses of unadjuvanted, inactivated pH1N1 vaccine 21 days apart. Hemagglutination inhibition titers were measured ...[more]

PMID: 23378284

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Dataset Information

Safety and immunogenicity of 2009 pH1N1 vaccination in HIV-infected pregnant women.

Background

Methods

Results

Conclusions

Publications

Safety and immunogenicity of 2009 pH1N1 vaccination in HIV-infected pregnant women.

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