Ontology highlight
ABSTRACT:
SUBMITTER: Yang SY
PROVIDER: S-EPMC3635078 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Yang Shu Yuan SY Baxter Ellen M EM Van Doren Mark M
Developmental cell 20120501 5
Establishment of germline sexual identity is critical for production of male and female germline stem cells, as well as sperm versus eggs. Here we identify PHD Finger Protein 7 (PHF7) as an important factor for male germline sexual identity in Drosophila. PHF7 exhibits male-specific expression in early germ cells, germline stem cells, and spermatogonia. It is important for germline stem cell maintenance and gametogenesis in males, whereas ectopic expression in female germ cells ablates the germl ...[more]