Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.
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ABSTRACT:
SUBMITTER: Nazarov I
PROVIDER: S-EPMC3635148 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
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Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.
Nazarov Igor I Lee Jae W JW Soupene Eric E Etemad Sara S Knapik Derrick D Green William W Bashkirova Elizaveta E Fang Xiaohui X Matthay Michael A MA Kuypers Frans A FA Serikov Vladimir B VB
Stem cells translational medicine 20120508 5
We describe human chorionic mesenchymal stem cell (hCMSC) lines obtained from the chorion of human term placenta with high therapeutic potential in human organ pathology. hCMSCs propagated for more than 100 doublings without a decrease in telomere length and with no telomerase activity. Cells were highly positive for the embryonic stem cell markers OCT-4, NANOG, SSEA-3, and TRA-1-60. In vitro, cells could be differentiated into neuron-like cells (ectoderm), adipocytes, osteoblasts, endothelial-l ...[more]
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