Ontology highlight
ABSTRACT:
SUBMITTER: Katsumoto TR
PROVIDER: S-EPMC3635736 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Katsumoto Tamiko R TR Kudo Makoto M Chen Chun C Sundaram Aparna A Callahan Elliott C EC Zhu Jing W JW Lin Joseph J Rosen Connor E CE Manz Boryana N BN Lee Jae W JW Matthay Michael A MA Huang Xiaozhu X Sheppard Dean D Weiss Arthur A
The Journal of clinical investigation 20130401 5
Increased airway smooth muscle (ASM) contractility and the development of airway hyperresponsiveness (AHR) are cardinal features of asthma, but the signaling pathways that promote these changes are poorly understood. Tyrosine phosphorylation is tightly regulated by the opposing actions of protein tyrosine kinases and phosphatases, but little is known about whether tyrosine phosphatases influence AHR. Here, we demonstrate that genetic inactivation of receptor-like protein tyrosine phosphatase J ( ...[more]