Ontology highlight
ABSTRACT:
SUBMITTER: Zhong Y
PROVIDER: S-EPMC3636790 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Zhong Yifei Y Chen Edward Y EY Liu Ruijie R Chuang Peter Y PY Mallipattu Sandeep K SK Tan Christopher M CM Clark Neil R NR Deng Yueyi Y Klotman Paul E PE Ma'ayan Avi A He John Cijiang JC
Journal of the American Society of Nephrology : JASN 20130404 5
The Connectivity Map database contains microarray signatures of gene expression derived from approximately 6000 experiments that examined the effects of approximately 1300 single drugs on several human cancer cell lines. We used these data to prioritize pairs of drugs expected to reverse the changes in gene expression observed in the kidneys of a mouse model of HIV-associated nephropathy (Tg26 mice). We predicted that the combination of an angiotensin-converting enzyme (ACE) inhibitor and a hist ...[more]