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Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila.

ABSTRACT: Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominently expressed in 10-13 pairs of R4 neurons of the ellipsoid body in the brain and functioned in these neurons for selecting appropriate foods.

SUBMITTER: Dus M

PROVIDER: S-EPMC3637869 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila.

Dus Monica M Ai Minrong M Suh Greg S B GS

Nature neuroscience 20130331 5

Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominent ...[more]

PMID: 23542692

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