Ontology highlight
ABSTRACT:
SUBMITTER: Sugiyama N
PROVIDER: S-EPMC3639392 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Sugiyama Nami N Gucciardo Erika E Tatti Olga O Varjosalo Markku M Hyytiäinen Marko M Gstaiger Matthias M Lehti Kaisa K
The Journal of cell biology 20130401 3
Changes in EphA2 signaling can affect cancer cell-cell communication and motility through effects on actomyosin contractility. However, the underlying cell-surface interactions and molecular mechanisms of how EphA2 mediates these effects have remained unclear. We demonstrate here that EphA2 and membrane-anchored membrane type-1 matrix metalloproteinase (MT1-MMP) were selectively up-regulated and coexpressed in invasive breast carcinoma cells, where, upon physical interaction in same cell-surface ...[more]