Ontology highlight
ABSTRACT:
SUBMITTER: Sampat KR
PROVIDER: S-EPMC3639530 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sampat Keeran R KR O'Neil Bert B
The oncologist 20130410 4
Hepatocellular carcinoma (HCC) is a significant cause of death worldwide. HCC is a highly vascular tumor, and proangiogenic cytokines such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and fibroblast growth factor may play crucial roles in this disease. Sorafenib, a multikinase inhibitor that blocks VEGF and PDGF signaling, was the first systemic therapy to demonstrate improved survival in patients with advanced HCC. Several other drugs targeting VEGF are i ...[more]