Ontology highlight
ABSTRACT:
SUBMITTER: Sanvitale CE
PROVIDER: S-EPMC3639963 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sanvitale Caroline E CE Kerr Georgina G Chaikuad Apirat A Ramel Marie-Christine MC Mohedas Agustin H AH Reichert Sabine S Wang You Y Triffitt James T JT Cuny Gregory D GD Yu Paul B PB Hill Caroline S CS Bullock Alex N AN
PloS one 20130430 4
Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogenetic protein (BMP) receptor kinase ALK2 (ACVR1) are needed urgently to treat the progressively debilitating musculoskeletal disease fibrodysplasia ossificans progressiva (FOP). Dorsomorphin analogues, first identified in zebrafish, remain the only BMP inhibitor chemotype reported to date. By screening an ...[more]