A new small molecule inhibitor of soluble guanylate cyclase.
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ABSTRACT:
SUBMITTER: Mota F
PROVIDER: S-EPMC4558462 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
A new small molecule inhibitor of soluble guanylate cyclase.
Mota Filipa F Gane Paul P Hampden-Smith Kathryn K Allerston Charles K CK Garthwaite John J Selwood David L DL
Bioorganic & medicinal chemistry 20150804 17
Soluble guanylate cyclase (sGC) is a haem containing enzyme that regulates cardiovascular homeostasis and multiple mechanisms in the central and peripheral nervous system. Commonly used inhibitors of sGC activity act through oxidation of the haem moiety, however they also bind haemoglobin and this limits their bioavailability for in vivo studies. We have discovered a new class of small molecule inhibitors of sGC and have characterised a compound designated D12 (compound 10) which binds to the ca ...[more]
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