Ontology highlight
ABSTRACT:
SUBMITTER: Fong HK
PROVIDER: S-EPMC3640380 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Marine drugs 20130128 2
A series of N-14 sidechain substituted analogues of styelsamine (pyrido[4,3,2-mn]acridine) and cystodytin (pyrido[4,3,2-mn]acridin-4-one) alkaloids have been prepared and evaluated for their DNA binding affinity and antiproliferative activity towards a panel of human tumor cell lines. Overall it was found that styelsamine analogues were stronger DNA binders, with the natural products styelsamines B and D having particularly high affinity (K(app) 5.33 × 10(6) and 3.64 × 10(6) M(-1), respectively) ...[more]