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?-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers.

ABSTRACT: The native function of ?-synuclein is thought to involve regulation of synaptic vesicle trafficking. Recent work has also implicated a role in neurotransmission, possibly through interactions with the proteins involved in synaptic vesicle fusion. Here, we demonstrate that ?-synuclein inhibits SNARE-mediated vesicle fusion through binding the membrane, without a direct interaction between ?-synuclein and any of the SNARE proteins. This work supports a model in which ?-synuclein plays a role in the regulation of vesicle fusion by modulating properties of the lipid bilayer.

SUBMITTER: DeWitt DC

PROVIDER: S-EPMC3640401 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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α-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers.

DeWitt David C DC Rhoades Elizabeth E

Biochemistry 20130327 14

The native function of α-synuclein is thought to involve regulation of synaptic vesicle trafficking. Recent work has also implicated a role in neurotransmission, possibly through interactions with the proteins involved in synaptic vesicle fusion. Here, we demonstrate that α-synuclein inhibits SNARE-mediated vesicle fusion through binding the membrane, without a direct interaction between α-synuclein and any of the SNARE proteins. This work supports a model in which α-synuclein plays a role in th ...[more]

PMID: 23528131

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