Dataset Information
?-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers.
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ABSTRACT:
SUBMITTER: DeWitt DC
PROVIDER: S-EPMC3640401 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
α-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers.
Biochemistry 20130327 14
The native function of α-synuclein is thought to involve regulation of synaptic vesicle trafficking. Recent work has also implicated a role in neurotransmission, possibly through interactions with the proteins involved in synaptic vesicle fusion. Here, we demonstrate that α-synuclein inhibits SNARE-mediated vesicle fusion through binding the membrane, without a direct interaction between α-synuclein and any of the SNARE proteins. This work supports a model in which α-synuclein plays a role in th ...[more]