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Transcriptional regulation and its misregulation in disease.

ABSTRACT: The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.

SUBMITTER: Lee TI

PROVIDER: S-EPMC3640494 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Transcriptional regulation and its misregulation in disease.

Lee Tong Ihn TI Young Richard A RA

Cell 20130301 6

The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease. ...[more]

PMID: 23498934

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