Ontology highlight
ABSTRACT:
SUBMITTER: Teijaro JR
PROVIDER: S-EPMC3640797 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130401 6129
During persistent viral infections, chronic immune activation, negative immune regulator expression, an elevated interferon signature, and lymphoid tissue destruction correlate with disease progression. We demonstrated that blockade of type I interferon (IFN-I) signaling using an IFN-I receptor neutralizing antibody reduced immune system activation, decreased expression of negative immune regulatory molecules, and restored lymphoid architecture in mice persistently infected with lymphocytic chor ...[more]