Ontology highlight
ABSTRACT:
SUBMITTER: Daugan M
PROVIDER: S-EPMC5136549 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Daugan Matthieu M Murira Armstrong A Mindt Barbara C BC Germain Amélie A Tarrab Esther E Lapierre Pascal P Fritz Jörg H JH Lamarre Alain A
Frontiers in immunology 20161205
Elicitation of type I interferon (IFN-I) has been shown to both enhance and impair cell-mediated immune responses in acute and persistent viral infections, respectively. Here, we show that, in addition to its effect on T cells, IFN-I drives impairment of specific antibody responses through interaction with B cells in the acute phase of lymphocytic choriomeningitis virus (LCMV) infection. This impairment was limited to the T cell-dependent B cell response and was associated with disruption of B c ...[more]