Ontology highlight
ABSTRACT:
SUBMITTER: Chung MI
PROVIDER: S-EPMC3640985 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Chung Mei-I MI Peyrot Sara M SM LeBoeuf Sarah S Park Tae Joo TJ McGary Kriston L KL Marcotte Edward M EM Wallingford John B JB
Developmental biology 20111229 1
In Caenorhabditis elegans, the RFX (Daf19) transcription factor is a major regulator of ciliogenesis, controlling the expression of the many essential genes required for making cilia. In vertebrates, however, seven RFX genes have been identified. Bioinformatic analysis suggests that Rfx2 is among the closest homologues of Daf19. We therefore hypothesize that Rfx2 broadly controls ciliogenesis during vertebrate development. Indeed, here we show that Rfx2 in Xenopus is expressed preferentially in ...[more]