Ontology highlight
ABSTRACT:
SUBMITTER: Wei L
PROVIDER: S-EPMC3641353 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Cell death & disease 20130418
Oroxylin A is a major active component of the Chinese traditional medicinal plant Scutellaria baicalensis Georgi, which has been reported as a potential anticancer drug. We demonstrated that, Oroxylin A inhibited the glycolysis and the binding of hexokinase II (HK II) with mitochondria in human breast carcinoma cell lines, which was dependent on sirtuin-3 (SIRT3). The level of SIRT3 in mitochondria was increased by Oroxylin A. Then SIRT3 deacetylated cyclophilin D, diminished its peptidyl-prolyl ...[more]