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A role for the RNA-binding protein MOS2 in microRNA maturation in Arabidopsis.

ABSTRACT: microRNAs (miRNAs) play important roles in the regulation of gene expression. In Arabidopsis, mature miRNAs are processed from primary miRNA transcripts (pri-miRNAs) by nuclear HYL1/SE/DCL1 complexes that form Dicing bodies (D-bodies). Here we report that an RNA-binding protein MOS2 binds to pri-miRNAs and is involved in efficient processing of pri-miRNAs. MOS2 does not interact with HYL1, SE, and DCL1 and is not localized in D-bodies. Interestingly, in the absence of MOS2, the recruitment of pri-miRNAs by HYL1 is greatly reduced and the localization of HYL1 in D-bodies is compromised. These data suggest that MOS2 promotes pri-miRNA processing through facilitating the recruitment of pri-miRNAs by the Dicing complexes.

SUBMITTER: Wu X 

PROVIDER: S-EPMC3641593 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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A role for the RNA-binding protein MOS2 in microRNA maturation in Arabidopsis.

Wu Xueying X   Shi Yupeng Y   Li Jingrui J   Xu Le L   Fang Yuda Y   Li Xin X   Qi Yijun Y  

Cell research 20130212 5

microRNAs (miRNAs) play important roles in the regulation of gene expression. In Arabidopsis, mature miRNAs are processed from primary miRNA transcripts (pri-miRNAs) by nuclear HYL1/SE/DCL1 complexes that form Dicing bodies (D-bodies). Here we report that an RNA-binding protein MOS2 binds to pri-miRNAs and is involved in efficient processing of pri-miRNAs. MOS2 does not interact with HYL1, SE, and DCL1 and is not localized in D-bodies. Interestingly, in the absence of MOS2, the recruitment of pr  ...[more]

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