HIF proteins connect the RB-E2F factors to angiogenesis.
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ABSTRACT:
SUBMITTER: Bakker WJ
PROVIDER: S-EPMC3646055 | biostudies-literature | 2013 Mar-Apr
REPOSITORIES: biostudies-literature
Publications
HIF proteins connect the RB-E2F factors to angiogenesis.
Bakker Walbert J WJ Weijts Bart G M W BG Westendorp Bart B de Bruin Alain A
Transcription 20130214 2
Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF. (1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development. ...[more]
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